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Nidulaxanthone A

This illustration is about the groundbreaking research, led by Porco's team. In their work they introduce a highly efficient method for producing biologically active compounds called nidulalin A and nidulaxanthone A. These compounds have promising applications as DNA topoisomerase II inhibitors. The team developed a streamlined synthesis process for nidulalin A, incorporating novel activation techniques and a crucial carbonyl desaturation step. They also achieved asymmetric synthesis through acylative kinetic resolution, showcasing a strategic approach to controlling molecular stereochemistry. The researchers then employed a solvent-free dimerization process to produce nidulaxanthone A from enantioenriched nidulalin A. This innovative work not only advances organic synthesis but also offers insights into chemical dimerization, with potential implications for various scientific fields.

In this illustration, I am showing a keystep in the synthesis of Nidulaxanthone A: the desaturation of one intermediate of the reaction using Bobbitt’s oxoammonium salt. Although not scientifically accurate, it shows salt's particles swirling around the molecule and building a double bond. It also feature the hydrogen being rmeove from the substrate.