Late-Stage Fonctionalization of Peptides

This illustration is inspired from an article that explores a breakthrough in the modification of peptides, small proteins crucial to drug development. Scientists present a novel method, called late-stage functionalisation (LSF), for efficiently modifying peptides with the aim of achieving precision in their modifications.

Traditionally, scientists have modified peptides using specific building blocks, limiting the potential for diverse modifications. However, this study introduces a breakthrough approach. It uses light (photocatalysis) and a unique type of molecule called arylthianthrenium salts. The focus is on a less common part of peptides called dehydroalanine (Dha), which occurs naturally.

The results are promising. The researchers have successfully modified peptides using their innovative method, even when dealing with peptides containing sensitive moieties. The method demonstrates versatility by working well in both small-scale (batch) and large-scale (flow) reactions.